From Plato right down to ‘open label’ or ‘honest’ placebos, this counter-intuitive cure has found ready prescribers and users. And let’s not forget the Bible. In Saint Jerome’s fourth-century translation of the Bible into Latin, Verse 9 of Psalm 114 became: placebo Domino in regione vivorum. “Placebo” means “I will please”, so the verse in English reads: “I will please the Lord in the land of the living.”
The first directly medical implementation of placebo treatment is recorder in 1752 by the Scottish obstetrician William Smellie, who wrote, ““… It will be convenient to prescribe some innocent Placemus, that she may take between whiles, to beguile the time and please her imagination”.
“For centuries, the word “placebo” was closely linked to deception and pleasing people. Recent studies of open-label placebos show that they need not be deceptive to work. Contrariwise, studies of placebos show that they are not inert or invariable and the basis for the current World Medical Association position has been undermined. The recent history of placebos seems to pave the way for more placebo treatments in clinical practice and fewer in clinical trials.”