Here’s a web slide show with Mike Campbell and Alan Jones presenting on placebos at the Interesting South Conference, 20th August 2009. They even came up with a consent form allowing a doctor to prescribe placebos as needed …!
It sounds counter-intuitive, but it seems that placebos are geting ‘stronger’ … or more to the point, the placebo effect is increasingly recognised as touching the heart of the overall process of healing and the nature of wellness. A fascinating article on this dynamic phenomenon in Wired magazine – looks like the debate is going mainstream!
And lest we forget … there’s money at stake. Big money.
According to this article from the ‘OnMedica’ medical website, doctors are being encouraged to consider the “meta-placebo” effect: ‘the healing belief that even fake/placebo treatments have positive effects . . . if both the doctor and the patient believe in the healing powers of the fake treatment, it does not matter that both know the treatment is fake’. No need to wait for medical tests to verify this hypothesis. A growing number have already experienced this effect using our Universal Placebos. See our Testimonials page.
Tuesday, 5 August 2008
Doctors could steer patients away from unproven alternative therapies if they could use dummy pills, suggests Dutch research.
Oskar van Deventer, a researcher from Leidschendam in the Netherlandspoints out that it is a well established medical fact that fake treatments do work.
If this is the case, he argues, doctors could include placebo pills in their medical armamentarium. But then the doctor might have to lie to the patient and this would present an ethical dilemma.
“On the one hand, the doctor does not want to lie to his patient. On the other hand, the effect of the fake treatment would diminish if the patient knows it is fake. For this reason, fake treatments are typically left to practitioners of so-called alternative medicine who are often not even aware of the ethical dilemma,” he writes in the journal Medical Hypotheses.
However he believes this is not the case as telling the truth about the dummy treatment would not stop it from being effective. This type of treatment is called the ‘meta-placebo’ effect.
“This is based on the healing belief that even fake/placebo treatments have positive effects. That is, if both the doctor and the patient believe in the healing powers of the fake treatment, it does not matter that both know the treatment is fake,” he says.
If such an effect does exist, it would solve a few complexities for today’s medics. They would not have to lie to patients when prescribing them placebos and by having such treatments at their disposal they could continue to regularly monitor patients’ symptoms whilst on the “treatment”. The doctor could also help to prevent people from using alternative medicine, which can be both expensive and risky to health.
The hypothesis that the “meta-placebo” effect exists needs to be tested before such treatments can become evidence-based medicine.
Using the equivalent to the gold standard of the double blind trial would create a challenge for such research as would the dilemma over which condition to test it on, he says, but he calls on readers to help meet those challenges in testing the effect.
The article follows figures published by the Prescription Pricing Authority last month that show a fall in the prescribing of homeopathic remedies by GPs from 83,000 in 2005 to 49,300 in 2007.
However separately, a pilot study from five NHS homeopathic hospitals found 60% of the 1797 patients treated with homeopathic remedies reported an improvement in quality of life.
The top four most treated conditions were eczema, chronic fatigue syndrome, menopause and osteoarthritis. Amongst those four, the proportion of patients that reported an improvement in quality of life after six visits to the homeopath varied from 59.3% for chronic fatigue syndrome and 73.3% for menopause. Overall, 30 common conditions were being treated by homeopaths.
Medical Hypotheses 2008; 71: 335–9; Homeopathy 2008; 97: 114-121
What a difference a mention in the NY Times makes! There’s been an incredible amount of web traffic generated by a website advertising ‘Obecalp‘ (‘placebo backwards), including a very lively debate at one of our favourite sites, Boingboing
In the Boingboing exchanges, most people are objecting to (a) enculturating kids into pill-popping behaviours, and (b) deceiving kids about the actual nature of the pill. Nobody’s gainsaying the operation of the so-called placebo effect, it seems to be more about the parenting issues …
I guess the same objections would be raised to behaviour like putting a Flintstones-themed band-aid on a bumped knee that didn’t actually need a band-aid, with the assurance that this would ‘make it better’…?
Two things, in defence of the placebo-as-pill approach (and astute readers will be aware that the placebo effect can also be engaged through sham injections, sham surgery … and possibly Mystical Words Uttered Backwards Under a Full Moon and so forth …
As conscious purveyors of placebos, we’re concerned with the potential of the placebo effect to inspire self-healing. We don’t recommend that people lie about or misrepresent our product: it’s a sugar pill, inert, side-effect free … BUT the placebo effect exists, and there is some evidence to show that people ingesting a placebo *in the awareness that it’s a placebo* may still gain some benefit. That’s the ‘honesty in parenting’ bit.
As to the pill-popping-culture bit, well … perhaps. One of our team is a homeopath, and consequently aware of the materialist critique that homeopathic remedies are also nothing else but placebos. In general, our feeling is ‘so what? If there’s no deception and misrepresentation, and the things actually work, what’s the harm?’
We understand the passion and the aggro, to an extent. Nobody likes the idea of ripping people off and leveraging the pain of children. But we can assure you there’s a case to be made for harmless and light-hearted exploration of the placebo effect, and especially for the questions it raises about the same pill-popping culture that encourages conventional practitioners to regularly use ineffective treatments (such as prescribing antibiotics for viral infections).
I had this great thing happen just after I got back after new year. I wasn’t offered a further contract at the college and so had to leave on the 18th January. I was so upset and it brought up all insecurities like not good enough or I have failed again . . . and I was in this flat in the city with no money coming in!
I got home in tears and had got off the phone from a friend after bewailing my fate ( gremlins going nuts inside) and I picked up the Placebo…I said to myself, “This is stupid, I cannot and will not go down again, I have to succeed” as I popped a pill.
You have no idea, well of course you have, but I suddenly I went into a total calm state and lay on the sofa and fell into a deep sleep. I woke renewed cooked a curry and got on with life. Soon after I was offered a new job teaching English to Indian Punjabi young men and women and it’s lovely . . . feel like I’m in India!
So I cannot tell you how incredible the peace and the sleep that descended on me was . . . incredible. I have told my all my friends that I can vouch for Placebo efficacy!I am going to be a great success!
Love to you Jane xxxxxx
One for those who can’t start the day without a caffeine hit. 😉
Want to know where we get the ‘up to 70% success’ claim in our packaging?
"The placebo response, noted as an early or nonpersistent improvement in response to an inactive agent, represents one of the most significant challenges in central nervous system (CNS) drug development. Despite a wealth of documentation, there is no commonly accepted definition of this phenomenon. However, it is agreed that there has been a significant increase in the placebo response in the last 20 years, particularly in clinical trials with antidepressant medications for major depressive disorder (MDD).
Estimates as high as 70% have been reported for CNS clinical trials. (our italics) Such large placebo rates have a significant impact on the cost and speed of drug development.
Since fewer than half of the depressed patients who receive active medications in psychiatric trials show clinically significant improvement, some critics claim that antidepressants are no better than placebo treatment, and their illusory superiority depends on poorly designed studies and biased clinical evaluations. In a set of six identically designed, three-arm, parallel controlled trials submitted to the Food and Drug Administration for an antidepressant drug, Leber reported that antidepressants could not be distinguished from placebo in five of the six studies."
Ref. Richard Entsuah, Phil Vinall: Potential Predictors of Placebo Response: Lessons From a Large Database, Drug Information Journal. Ambler: 2007. Vol. 41, Iss. 3; pg. 315, 16 pgs
Amazing placebo experiment with knee surgery – points to the finding that there can be ‘grades’ in the placebo effect – big pills are more effective than small pills, coloured pills more effective than white ones, inert injections more effective than pills, and sham surgery more effective than any of them.
Of course, at Universal Placebos we feel it sufficient to stay with our modest, aesthetically pleasing, small white sugar pills, in doses of three. That’s enough.
One of the rare studies into the action of the placebo effect in ‘non-blind’ clinical trials was undertaken by Lee C. Park and Uno Covi at the Johns Hopkins University School of Medicine in 1964. ‘Non-blind’ means that patients were informed that the pills they were issued were totally inert, that they were placebos, and in this case they were also assured that despite this the pills would be of benefit to them. The study concluded:’The primary finding is that patients can be willing to take placebo and can improve despite disclosure of the inert content of the pills; belief in pill as drug was not a requirement for improvement.’
(Some first-hand reports on our Testimonials page.)
Ref. L. C. Park, U. Covi, Nonblind Placebo Trial – An Exploration of Neurotic Patients’ Responses to Placebo When Its Inert Content Is Disclosed, Archives of General Psychiatry, April 1965, Vol. 12, pp. 336-345
Placebo As Good As Common Treatments For Sinus Infections
A placebo is likely to be just as effective as common acute sinusitis treatments involving a topical steroid and an antibiotic, according to an article published in the Journal of the American Medical Association.
Ian G. Williamson, MD; Kate Rumsby, BA; Sarah Benge, PhD; Michael Moore, FRCGP; Peter W. Smith, PhD; Martine Cross, BA; Paul Little, MD – “Antibiotics and Topical Nasal Steroid for Treatment of Acute Maxillary Sinusitis – A Randomized Controlled Trial”, Journal of the American Medical Association. 2007;298(21):2487-2496.