We note an interesting ‘counter narrative’ emerging – that is, scepticism about the commonly held view that drug treatments designed for mood disorders such as depression often engage the Placebo Effect. In this counter-narrative,
“Drug trials don’t show much in the way of classic placebo effects. The rise in placebo responses over the years is more likely due to the supportive factors in drug trials…and increasing problems with enrollment.”
The new finding—no upward trend in placebo responses—is unexpected and certain to be contested. Meanwhile, it stands as a rebuke to a popular narrative. By that account, drug effects had been hyped, expectations soared, and the inflated hopes were reflected in rising placebo response rates.”
This is fine, except the counter-narrative also resonates with challenges about the efficacy of conventional ‘gold-standard’ ‘blind’ ‘placebo controlled’ drug trials, where it has been shown that trials funded by drug companies (who by definition have a vested interest in their outcome) are 30% more likely to return ‘favourable’ results than trials which are not funded in this way. The ‘placebo effect’ might be the design and execution of the trial itself, not the actual function and efficacy of the placebo …!
Read the whole article here.
“Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin in the brain. Indeed, their supposed effectiveness is the primary evidence for the chemical imbalance theory. But analyses of the published data and the unpublished data that were hidden by drug companies reveals that most (if not all) of the benefits are due to the placebo effect. Some antidepressants increase serotonin levels, some decrease it, and some have no effect at all on serotonin. Nevertheless, they all show the same therapeutic benefit. Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.”
More on the continuing critique of widespread prescription of antidepressants here.
If a drug company treats a doctor to a nice lunch and a presentation on their newest products, is prescribing affected? Doctors generally think not, but the research evidence overwhelmingly says yes. And if these events do affect doctors’ decisions on patient care, should we be worried?
Couldn’t they just prescribe placebos? Of course not! Where’s the profit in that?
Placebo beats pill for all but most severely depressed, study shows.
“Antidepressants are little better than placebos except for in severely clinically depressed samples,” Johnson said. “The implication was that medical doctors are overprescribing antidepressants because most patients are not severely depressed.”
A journey to the land of “I Shall Please”
“I grew up in Marin County, California—a hotbed of holistic health, where “healers” of all stripes (legitimate or not) thrived. My own father was an acupuncturist who treated most of my ailments with tiny silver needles or stinky Chinese herbs. I went to the doctor only for routine physicals and shots required for school. Thus, I grew up believing that my body had the power to heal itself.
Once I left home and moved to the more conservative burbs of Santa Clara County, I came to realize that the average person considered alternative medicine to be a placebo at best—and an outright sham at worst. But perhaps placebos have been getting a bad reputation. New research into the placebo effect suggests that our expectations and beliefs can play a much bigger role in healing than previously thought.”
Read the rest of the article here.
” … Drug companies have a strong financial incentive to game (i.e. fake) drug testing. To develop a new drug, they invest over a billion dollars and many years, with the reward contingent upon negotiating a sequence of RCTs, which opens the path to a patent-protected monopoly.”
Disturbing stuff. Read the full article.
More on the Americans developing a ‘tolerance’ to placebos. Can the answer be genetic?
In May, researchers from Harvard Medical School described a set of variants in 11 genes that they say are linked to the placebo effect and called it the ‘placebome.’ Scientists have known for quite some time that some people are more prone to experiencing the effect than others. And early investigations implicated the body’s natural pain control systems, including the opioid-like chemicals made and released in our own brains.
Research published in August 2015 (Increasing placebo responses over time in U.S. clinical trials of neuropathic pain) and published in the Journal Pain focused on over two decades’ worth of clinical trials – 80 in all. The results showed that, as many have speculated, our placebo response is indeed getting stronger. And, because one measure of a drug’s effectiveness is its ability to perform better than the placebo, more pain-drug trials are failing than in the past. But, interestingly, the researchers found that this increase was only true for studies conducted in the U.S.
A scary story in Salon about overt corporate deception in the marketing (even just the *naming*!) of certain drug products – as in the ‘repackaging’ of Prozac by Eli Lilly to exploit new markets. As in other, non-pharmaceutical marketing, cultural expectations play an enormous role.
‘I suggested to Moerman how odd it is that the meanings we ascribe to a pill can sometimes be more powerful than its active substance, especially in the realm of psychopharmacology.
“Well, James, you’re an anthropologist, right? You know the power of meaning! Every culture has its symbols and objects of veneration and it is no different with us. Once, for us, we revered crosses and statues of the Virgin Mary, but now pills and stethoscopes capture our worship. So even an inert pill can affect us because it has shape and form and a context, and it has language attached. It comes in a blue box or a pink box, it’s taken in a pharmacy, doctor’s room, or hospital with all the panoply of a thousand years of medical tradition behind it to give it overwhelming symbolic weight.”‘
Yet more science on the placebo effect, with a focus on “the impact of the reputation, charisma and convictions of the doctor administering (placebo)”.
“The concept of the self being an autonomous being is a deeply held belief in western civilisation, but we affect each other all the time.”